David Arquette's Star-Studded Birthday Wish

ETonline gave you an exclusive peek at David Arquette's trip to Senegal on behalf of Malaria No More, and now we're pleased to present the first look at his star-studded PSA!

Conan O'Brien, Josh Groban, Elizabeth Banks, John Mayer, Ed Helms, Jeff Probst, Lake Bell, Scott Wolf and Sara Gilbert join birthday boy Arquette in sharing their childhood hopes -- and how you can help them prevent Malaria from ruining a new generation's dreams. Check out the clip above and then click here to find out how you can help!