"It is with careful consideration and mutual respect that we have decided to end our marriage," the couple said in a statement. "Our primary concern remains the wellbeing of our children, and we ask with profound gratitude that you respect our family's privacy at this very sensitive time."
Dempsey, 49, and Fink are the parents of three children, 12-year-old Tallulah and 7-year-old twins Sullivan and Darby.
The actor was reportedly in Daytona Beach, Fla. for a racing event at the time of his wife’s divorce filing.
This would be Dempsey's second divorce. He was previously wed to actress Rochelle Parker from 1987 to 1994.
Dempsey is one of the highest-paid actors in TV, making a reported $16 million in 2014 from his Grey’s Anatomy stint and endorsement deals. Watch the video below for television's other top-paid actors.