Lawrence, in her signature quirky way presented the celebrated star with a touching and personal speech.
"As one of the greatest actors who's ever lived, I can learn a lot from him but the most important thing that he's taught all of us is acceptance," Lawrence said during her touching introduction. "Bob is the kindest person I've ever met. His heart is so giving and with his own quiet strength it’s no wonder that this man, and the incredible organization that is GLAAD, would come together tonight."
On his way up to the stage, De Niro happened to take a stumble on the steps, but the 72-year-old screen legend played it off as a tribute to Lawrence, who famously slipped on her gown at the Academy Awards while going on stage to accept her Oscar in 2013.
After taking the mic, De Niro smiled before joking with the 23-year-old actress, "If I were a lesbian, I'd be all over you."
The documentary De Niro produced, Remembering the Artist, tells the story of the actor's father, Robert De Niro, Sr., who was a gay artist struggling for acceptance in a difficult time.
"I wanted to make sure that I documented [my father's] life because, to me, he was a great artist -- You could see by his work and how much he had done and how prolific he was," De Niro shared with ET. " I did the documentary for my family, for friends, [and for] my kids, to know what their grandfather did."