"Well, it's going to be so fun," Roberts told DeGeneres. "They are a great couple and I think they don't need advice from me or anyone else because, also, nobody's there with you at 3 o'clock in the morning when you're just going, 'What am I doing? Where did they come from and when are they going?'"
"And then you sort of get through it and figure it out," she added. "And everybody does, and it's a trial and error and a whole lot of tears and it's amazing. I have three incredible kids and to think about when they were teeny tiny. It goes so fast."
Roberts will next be seen participating in Red Nose Day by making an appearance on Running Wild With Bear Grylls. The Oscar-winning actress teamed up with the survivalist to deliver vaccines to a remote village in Kenya as part of NBC's May 25 TV special.
Last month, the Pretty Woman star was also named People magazine's World's Most Beautiful Woman for a record fifth time. Watch below to see what she had to say about being given the title once again.