As a woman in her 60s, Winfrey notes that she's learned to "take no s**t."
"In your 40s, you want to say you, 'Take no sh**,' but you still do. In your 60s, you take none," she says of aging. "There’s both a quickening and a calming -- there’s a sense that you don’t have as much time on earth as you once did…people coming with anything less than what is the truth or authentic? Don’t even try."
Though Winfrey is not seem keen on getting into politics, she has taken a leadership role in the anti-harassment movement, Time's Up, and says women coming forward and sharing their experience with sexism and assault has brought "a level of awareness that was not there before."
"That’s the most important thing to me," she continues. "When Reese Witherspoon can tell her story at the same time as a farm worker in Iowa or a factory worked in Alabama, it says to a person, ‘Oh well, I’ve been putting up with that asshole supervisor for all these years. Maybe it’s time for me to do something too.'"