The 63-year-old multifaceted media mogul accepted the Cecil B. DeMille prize for her contributions to the world of entertainment – and left many awestruck with her powerful speech.
Winfrey began her speech by sharing her memory of Sidney Poitier winning his Oscar in 1964, and then being honored with the Golden Globes' Cecil B. DeMille Award in 1982.
"There's some little girls watching as I am the first black woman to be given the same award. It is an honor, and it is a privilege to share the evening with all of them, and also with all the men and women who have inspired me, challenged me, sustained me and made my journey to this stage possible," she shared, thanking those close to her, like Gayle King and Stedman Graham, before noting the importance of "speaking your truth."
"I want, tonight, to express gratitude to all the women who have endured years of abuse and assault because, like my mother, they had bills to pay and dreams to pursue," Winfrey shared, telling the story of Recy Taylor, and declaring that "time is up" for those who use their positions of power to abuse others.
"I want all the girls watching here now to know that a new day is on the horizon!" she said, as the audience raised from their chairs and erupted in applause. "And when that new day finally dawns, it will be because of a lot of magnificent women, many of whom are here tonight, and some pretty phenomenal men, fighting hard to make sure that they become the leaders who take us to the time when nobody has to say, 'Me too,' again!"
This isn't the first time Winfrey opened up about her feelings regarding sexual misconduct, previously telling ET, "It's a really powerful time for everybody to get woke."
"Not just about sexual harassment, but about the way you view somebody who has less power than you do. This is really a question about power and the misuse and abuse of power. I think this is a time for those of us who do hold some to come together and to see what we can do to further this moment," she stated.
Meanwhile, President of the Hollywood Foreign Press Association Meher Tatna told ET on Thursday how deserving the Wrinkle in Time star was of this award.
"Oprah has a way of connecting with people," Tatna expressed. "That is her gift. She reaches through the TV and reaches people and connects with them. She is a role model for strong, independent women everywhere. She's respected. I mean, it was a no-brainer for us."