Winfrey spoke with Today'sHoda Kotb about the critics of the couple, who point out that they both ask for privacy from unwanted media attention and have recently been very public about their personal struggles.
"You know, I ask for privacy, and I'm talking all the time," Oprah quipped. "So I think being able to have a life that you are not intruded upon by photographers or people flying over head or invading your life is what every person wants and deserves. That's what people are missing. Privacy doesn't mean silence."
"They have not shared any regrets with me," Oprah said of the Duke and Duchess of Sussex. "I understood what had happened to them, and I wanted the rest of the world to come away being able to answer the question, 'Why did they leave?' I think by the time that interview was done, people understood."
The Me You Can't See director Dawn Porter told ET that "Oprah and Harry have become close."
"Oprah started crying when he was telling the story of his mother, [Princess Diana]," she recalled of filming the docuseries with the two. "I don't know how many of us thought about what it would feel like to be a little boy walking for a long distance, following your mother's casket."
For more from the docuseries, watch the clip below.