"Quarantine Stir Crazy," Wilson, 63, captioned a video of herself. "See it to believe it."
The video shows Wilson reading a copy of the famed Orson Scott Card sci-fi novel Ender's Game before hearing Naughty By Nature's "Hip Hop Hooray." Looking up from her book, Wilson shows off her skills by rapping along with the classic track.
During Monday's episode of CBS This Morning, Gayle King revealed that she reached out to Wilson to tell the actress that the video was "hilarious."
"[Rita] said she had done it in a movie years ago called Boy Genius and she had memorized it and wanted to see if [she] could still remember it... and she did," King said. "... Good job, Rita Wilson, it is good to know they are both getting better."
"I thought what an odd choice and she goes, 'No, no, it's in a movie,'" King added. "I would've never put hip-hop and Rita together, but there you go. And she's good at it too!"
Wilson and Hanks were released from a Queensland hospital last week, and entered self-quarantine at a rented home in Australia.
The pair traveled to Australia so that Hanks could participate in the state of pre-production on Baz Luhrmann's upcoming Elvis Presley biopic, in which the actor plays Presley's longtime manager, Colonel Tom Parker.
Warner Bros. Pictures revealed in a statement to ET last week that they were working with Australian health agencies to identify and contact anyone who may have come in direct contact with the virus.
"Hello, folks. Rita and I are down here in Australia. We felt a bit tired, like we had colds, and some body aches," Hanks shared. "Rita had some chills that came and went. Slight fevers too. To play things right, as is needed in the world right now, we were tested for the Coronavirus, and were found to be positive."
"Well, now. What to do next? The Medical Officials have protocols that must be followed," he continued. "We Hanks’ will be tested, observed, and isolated for as long as public health and safety requires. Not much more to it than a one-day-at-a-time approach, no? We’ll keep the world posted and updated. Take care of yourselves!"