The first track off of The Weeknd's new EP, "Call Out My Name," appeared to spark the most Gomez speculation, beginning with, "We found each other/ I helped you out of a broken place/ You gave me comfort/ But falling for you was my mistake."
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Selena Gomez's Friends Still Don't Approve of Justin Bieber (Exclusive)
Things seem to get even more personal with the lines, "I put you on top, I put you on top / I claimed you so proud and openly / And when times were rough, when times were rough / I made sure I held you close to me," which could possibly reference both how open they were with making public appearances together as well as how The Weeknd canceled shows to be by Gomez's side during her health struggles.
Fans also noticed another possible reference about Gomez's kidney transplant. Watch below.