Sophia Bush Dishes on First Onscreen Kiss Ever With Ryan Reynolds (Exclusive)

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Onscreen kisses can obviously be awkward, but it turns out Sophia Bush's first time was a great experience, thanks to her co-star -- none other than Ryan Reynolds.

ET spoke to Bush on Tuesday about partnering up with PayPal on #GivingTuesday, a movement fueled by social media to kick off the charitable season. Bush also reminisced about this year being the 15-year anniversary of Van Wilder, the 2002 film in which she appeared alongside Reynolds and Tara Reid.

"That was my first job," the 35-year-old actress tells ET. "Truly I just remember Ryan Reynolds being the most professional and kind and courteous man. You want to talk about good men in Hollywood -- aces all around. Such a good human being."

"To walk in as an actor and have your first onscreen kiss with somebody, and not know what's going on ... I said something about it being my first day and he was like, 'Here's a few things you need to know,' and gave me just little technical tips that were so helpful, [which] put me completely at ease," she continues. "And yeah, he's just the best."

These days, Bush couldn't be happier for Reynolds' professional success, as well as his role as father to two daughters -- James and Ines -- with wife Blake Lively.

"Over all the years that I've seen him and I've watched his career, he'll be like, 'I just saw you on this and you were great,'" she shares. "And I’m like, 'I saw this movie and I loved it.' To watch him become this incredibly happy dad ... I don’t know, he's one of those people that I really root for. It's crazy to think that it's been that long."

Bush is also totally down to collaborate with both him and Lively!

"I'd love for him and Blake to come and work on anything that I'm doing," Bush says. "They're both incredible humans and just the funniest people on the planet. Yeah, I'm in!"

But one thing she's definitely not interested in is a reboot of One Tree Hill, the beloved teen drama she starred on from 2003 to 2012. Bush makes it clear there are no plans to revive the series.

"I mean, we all talk quite regularly," she says of the tight-knit cast, which includes Hilarie Burton and Chad Michael Murray. "But yeah, I don't think there's any of that in the future. ... We did it for nine years."

Currently, Bush is passionate about philanthropy, as well as empowering women in schools, and of course, in Hollywood.

"I think we have to listen to women. We have to believe women. That's paramount, right?" Bush notes about how people can improve the space for women. "But we also have to look at the ways in which decisions are made, and who they're being made by. And its not a criticism of men necessarily. Being a feminist does not mean you're a man hater. But the reality is, men have half the information and we have the other half. And so, if all of the decisions are being made by men, they're missing half the information. So there needs to be a better balance in every industry, in every community, in every place that decisions are being made and where power is controlled."

Given her passion for policy and outspokenness on current issues, would Bush ever consider running for president of the United States?!

"It's so tremendously sweet," Bush says of the compliment. "I mean, advocacy is part of who I am and what I believe in. I certainly wouldn't rule it out."

Bush Instagrammed about her Giving Tuesday partnership with PayPal on Tuesday. Paypal will add one percent to every donation made here. 

In January, Bush eloquently wrote about her past relationships and why she's no longer looking for "the one" in an op-ed for Cosmopolitan.

Watch below:


'One Tree Hill' Cast & Crew Issue Statement on EP's Alleged 'Traumatizing' Behavior

Sophia Bush Sends Sweet Birthday Message to 'One Tree Hill' Co-Star Hilarie Burton: 'Breyton 4eva'

Sophia Bush Leaving 'Chicago P.D.' After Four Seasons