Ann Dowd, Juliette Lewis and Taryn Manning Bring Family Drama to 'At Home With Amy Sedaris' (Exclusive)

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There has been no shortage of A-list guest stars on season two of At Home With Amy Sedaris. And ET has your first look at Ann Dowd, Juliette Lewis and Taryn Manning -- TV's dream trio -- who all make a hilariously unexpected appearance on this week's all-new, hospitality-themed episode. 

When frenemy Chassie (Cole Escola) falls ill, Amy Sedaris takes advantage of the opportunity to show audiences how to care for the sick in your very own home. In addition to setting up a sick room and preparing homemade chicken soup, the host says "another way you can help the ill heal is to round them with love."

In Chassie's case, that's begrudgingly being surrounded by the Tucker family, including mother Terry (Dowd), sisters Tandy and Tafney (Lewis and Manning) and granny Tucker (Sedaris). It's safe to say that the visit doesn't do anything to raise Chassie’s spirits. 

Also appearing in this week's star-studded episode are Fred Armisen and Leo Fitzpatrick

"It’s ridiculous," Sedaris said of the surplus of stars this season. When describing to ET what it was like to work with "real actors" like Dowd or previous guest star Rose Byrne, Sedaris said "I can't even believe I'm in a scene with that person."

At Home With Amy Sedaris
TruTV

But for all the guest stars, the real breakout is Escola, who joined as a writer in season two in addition to recurring on screen as Chassie. "It's why he’s in every episode," Sedaris joked about Chassie’s increased -- but welcomed -- screen time in season two.

While the two briefly worked together on Hulu's Difficult People, it was after seeing his orange juice commercial parody on YouTube that Sedaris said "that person needs to be my neighbor on the show."

"We hit it off immediately," Sedaris revealed, adding that he's "really great in the writers' room."

At Home With Amy Sedaris airs Tuesdays at 10 p.m. ET/PT on TruTV.

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