When asked if she's feeling excited about Meghan Markle and Prince Harry tying the knot next month, Theron gushed, "Oh my gosh, yes! I mean, everybody's excited about it, right? I think it's great."
Theron -- who famously spent an afternoon with Prince Harry at a charity polo match in the U.K. in 2011 and was once incorrectly rumored to be on the guest list for the royal wedding -- said she's "a big fan" of the 33-year-old groom-to-be.
"He's a great guy," she said. "I don't know her, but I know he has good taste so I wish them the best… and I'll be watching!"
Theron also opened up about her new film, Tully, in which she stars as Marlo, a beleaguered mother of three young children, struggling with the pressure and stress of a new baby, who hired a young night nanny, the eponymous Tully, with whom she forms an intense bond of friendship.
'Tully' Trailer: Charlize Theron Exposes the Reality of Motherhood in New Comedy
In the film -- which was written by Diablo Cody and marks Theron's second starring collaboration with director Jason Reitman after 2011's Young Adult -- the actress finds she can lean on her young night nanny for help when she's feeling overwhelmed by life.
However, in Theron's real life, she says the person she always turns to first when she's struggling with an emotional or existential crisis, is her mom.
"She's hands down my Tully, yeah. I'm just so lucky to have a parent who just gets it," Theron, who has two children, explained. "Sometimes she just looks at me and she gets it and she shows up and she's there and she has my back and I can't imagine doing this without her."