"I mean, this is such a different way of going after bad guys every week, you know?" Rodriguez tells ET.
While the CSI crew focused on the empirical evidence to bring criminals to justice, the Criminal Minds profilers at the FBI Behavioral Analysis Unit analyze serial killers to anticipate their next moves before they strike again.
But, of course, fans would certainly like to see Rodriguez do more than just catch criminals on the show. While he's off the market in real life, as he and Grace Gail married in May, he's leaving the possibility open for an on-screen love interest.
"I'm always up for a little romance," Rodriguez admits. "I think it's a part of life. It makes things fun."
Rodriguez couldn't have picked a more pivotal season to start on the show. In addition to Moore's farewell, Thomas Gibson was fired from the program following an on-set altercation with a writer and will only be featured in the first two episodes. Meanwhile, Aisha Tyler was promoted to a series regular and the team is on the hunt for 13 suspects who broke out of prison in the season 11 finale.
Find out how it all unfolds when Criminal Minds returns to CBS Wednesday at 9 p.m. ET/PT.