A spokesperson for the Miami-Dade Medical Examiner’s Office tells ET that an autopsy was conducted on Wednesday. The medical examiner ruled that Horta died by suicide.
Horta's agent confirmed with ET that the writer and producer died in Miami shortly after his body was discovered by authorities. He was 45.
Horta’s mother, Anna, and sister, Hilda, released a statement to ET addressing the tragic news.
"It is with great sadness that we announce the passing of our dear brother and son, Silvio Horta. Through his friendships, his love and his work in TV and films, Silvio touched the lives of millions," the family shared. "Silvio had an ongoing struggle with addiction and depression, but through it all, he always found a way to turn his struggle into laughter. He was a kind and beautiful man. He may be gone but his light will shine on."
ET has learned that a service will be held in Miami, with a memorial service to be announced in Los Angeles.
A source who was close to Horta told ET on Tuesday that he'd struggled with addiction in recent years.
Horta was showrunner and head writer on the popular ABC series, which was adapted from the Colombian telenovela Yo soy Betty, la fea.
The four-season show premiered in 2006 and made stars of actors America Ferrera and Michael Urie. It won a Golden Globe Award for Best Television Series - Musical or Comedy in 2007, with Horta taking the stage to accept the award.
Horta also worked on Jake 2.0., starring Christopher Gorham.
See more on Ugly Betty below.
If you or someone you know needs help, please call the National Suicide Prevention Lifeline at 1-800-273-TALK (8255).