The former morning show host married the Dutch-born model in 1998 in Bridgehampton, New York, and the couple has often put up a united front in public, despite facing years of tabloid rumors of Lauer allegedly having affairs.
"I go home and live my life and with my family and, you know, smile when I read some stuff and laugh," Lauer said at the UNICEF Snowflake Ball in 2005, with Annette adding, "And cry."
"As long as my kids and our family and our friends know the real story, that's all we care about," Lauer noted.
The two were last seen publicly with each other in September, heading to lunch in New York City.
But despite brushing off the allegations of infidelity, Lauer and Roque's marriage has not been without turmoil.
In 2006, Roque reportedly filed for divorce against her husband before eventually withdrawing the documents, per The New York Daily News. According to paperwork first obtained by the National Enquirer, in the filing, Roque accused her husband of "cruel and inhumane acts," reportedly also claiming that Lauer was controlling about "even the smallest decisions," alleging he showed "extreme anger and hostility" toward Roque.
The couple, who share three kids, reconciled, and in June 2016, Lauer purchased a $36.5 million North Haven, New York, estate from actor Richard Gere.
Past allegations of infidelity prompted a response from Lauer's first wife, TV producer Nancy Alspaugh, who was married to Lauer from 1981 until 1988.
"The reason my marriage to Matt ended was not because of infidelity on his part," Alspaugh said in a 2005 interview.