The 71-year-old actress' latest role in 'The Wife' could be the one to finally earn her that statuette.
ET spoke with Close about being nominated six times, but never yet winning an Academy Award.
'The Wife,' which co-stars Jonathan Pryce, Christian Slater and Max Irons, opens in theaters on Aug. 17.
ET has a look at Close's powerful turn in the chamber piece, which co-stars Jonathan Pryce and Christian Slater.
The drama series ran from 2007 to 2012.
Anderson stars alongside Glenn Close, Christina Hendricks and Max Irons in the big screen adaptation of Agatha Christie's classic, available on iTunes and On Demand now. It comes to theaters on Dec. 22.
The 70-year-old actress worked closely with both actors throughout her career.
The 70-year-old actress opened up to ET about her lasting friendship with Michael Douglas on the red carpet at the 71st Annual Tony Awards, which air live on CBS.
The celebrated actress opened up to ET at the Tony Awards on Sunday about her iconic thriller and her close bond with her former co-star.
LuPone only likes one person in on-screen musicals today.
'The Girl With All the Gifts' is available on DirecTV Jan. 26 and in select theaters from Saban Films Feb. 24.
The comedy hits theaters Jan. 27.
The race for the White House has made it to Broadway.
ET can confirm the actress and her third husband have split.