The reality star made the announcement in an emotional blog post on her website on Tuesday, titled "Goodbye RHOC."
"As you might suspect filming this show takes a massive emotional toll," Edmonds, 33, explained. "I loved being a Housewife and was so grateful for my opportunity. It was only after the season was filmed that I felt I was finally out of the newborn fog and I could look back on the past few months of season 12 with clarity. I had no idea how exhausted I actually was until I wasn’t exhausted anymore! Season 12 was a real challenge for me."
In the post, Edmonds reveals she is relocating back to her hometown of St. Louis, Missouri, writing, "I wanted to spend more time with my husband during baseball season and more time with my two young step kids who live full-time in St Louis."
Interestingly, Edmonds, who is currently expecting twins, had planned to stay on for season 13, before her exhaustion at the prior season's reunion showed her that it wasn't going to be possible.
"As I was filming the season 12 reunion I knew in my heart I was done: this wasn’t my place anymore. (The funny thing is that going into the reunion I was so committed to coming back for season 13; just one more season before the twins were born.)," she shared. "I was only 5 weeks pregnant when I filmed the reunion and I was already exhausted. I knew that I was going to have a long pregnancy growing the twins and it would be next to impossible to film."
"I must focus on my family and my pregnancy," Edmonds concluded her post. "I have made soul sisters in Shannon Beador and Tamra Judge and that can’t be lost. They have touched my heart and I would do anything for them and I know they feel the same way about me – what a gift to have found that on RHOC! But I guess it’s time for me to become an actual real housewife of sorts. Oh, the irony!"
Meanwhile, one past Housewife may be returning to the show.
In November, Heather Dubrow told ET why she left, as well as leaving the door open for a possible return.
“You know, I think it was really good to take a break and take a step back,” she explained.
As for possibly coming back: "Never say never,” she said. “Real Housewives of Orange County was an incredible experience for me. Five years, made great friends, had amazing experiences and, quite honestly, it was a terrific platform for everything that Terry and I have done, and for our family, so I'm very, very grateful. As for the future, never say never.”