The late-night host asked some of Hollywood's biggest stars to read the awful things written about them on Twitter, and per usual, the results were nothing short of spectacular.
Hail, Caesar! star George Clooney brought his charm and gravitas to a dramatic reading of @Tann_Matt's tweet, "If that gross ratty old man George Clooney can find a girl… you regular fella out there in the Twitterverse must be drowning in p***y."
The Danish Girl's Eddie Redmayne read a tweet from @Reemawi, who wrote, "[It] looks like someone tried to erase his nose, but couldn't completely. I also think he looks perpetually dehydrated."
"Which I am," the Oscar winner added. "I am really thirsty!"
Twitter user @pattywhacker's mean remarks just made actress Susan Sarandon laugh. "Tired of Susan Sarandon having her big fat saggy in my face," the 69-year-old star recited.
"Oh, you wish," she quipped.
Empire star Taraji P. Henson brought some aggression into the mix when she read @aMUSIC_nerd's tweet stating the actress, "seems like she's extremely ghetto in real life, lol."
"Well I can be b**ch!" Henson responded. "Meet me outside!"
This epic installment also featured Christoph Waltz, Patricia Arquette, Jessica Chastain, Kevin Costner, Emily Blunt, Zach Galifianakis, Kevin Hart, Richard Dreyfuss, Cate Blanchett, Seth Rogen and Oscar Isaac.
Even legendary curmudgeon Sean Penn got in on the fun, reading a particularly harsh tweet from @Jenny_IDLYITW that graphically compared the different parts of his face to genitals. Where else but on "Mean Tweets" would you see a thing like that?
There's something amazing about watching famous people, whose lives are filled with accolades and praise, coming face to face with anonymous jerks spouting off horrendous nonsense.
Jimmy Kimmel Live! airs weeknights at 11:35 p.m. ET/PT on ABC.