The Grinder star couldn't help poking a little fun at his longtime pal Sean Penn on Sunday's Golden Globes red carpet, weighing in on the news that Penn had secretly interviewed Mexican drug lord El Chapo for Rolling Stone.
"Did Sean catch him?" Lowe asked ET's Nancy O'Dell, throwing it way back to 1982 with a priceless Fast Times at Ridgemont High reference. "To me, it almost seems like Jeff Spicoli trying to cut out the middle man."
Before they were famous, Lowe and Penn were classmates at Santa Monica High School, along with Charlie Sheen and Robert Downey Jr.
"Listen, it's a big accomplishment from [a] fellow Santa Monica High [student]," Lowe cracked. "Look, the people who went to Santa Monica High -- we get s**t done. Let's face it. We do! We find drug lords, we get nominated for Golden Globes, we do a lot of stuff."
Lowe is nominated for his very meta role as an actor in The Grinder at this year's ceremony.
"I love that our funny little show has been recognized so early. We're only eight or nine episodes in, so to get this nomination -- it's a tribute to how good the show is," Lowe gushed.