On Wednesday, Angel shared a video to Instagram of his son speaking with a counselor while his tearful mom, Shaunyl Benson, and dad sat next to him.
"It's OK to feel sad. I'm angry this happened to you again. That is not fair," the counselor told Johnny before explaining what his leukemia does to his health.
The counselor also gave Johnny several visuals to help him understand his condition and how he might be feeling. "Thank you @cure4thekids and all for your thoughts and prayers. ❤️ #1095," Angel captioned the post.
In addition to the emotional video, Angel shared pics of his family, including a few of his 10-month-old son, Xristos.
The proud father also shared a video on his Instagram Story of Johnny jumping up and down with his brother. "How can he have anything wrong," Angel wrote over the video. "He's full of life, love and happiness."
After Angel told TMZ cameras the sad news about his son, he released a statement to ET. "We have recently had confirmation that our 5-year-old son Johnny Crisstopher has relapsed with ALL (acute lymphoblastic leukemia). While we are devastated by this unexpected news, we believe that he will be in remission again soon," he said. "We have great faith and hope for his treatment at both Summerlin Hospital and Cure 4 the Kids Foundation with Dr. Alan Ikeda, who has been treating Johnny Crisstopher in Nevada. He is an amazingly strong little boy, and with the support of family, friends, and my loyal fans we look forward to the day he is again in remission."
Angel's statement also noted how he and his family plan to help other families who are dealing with similar struggles. "This setback only continues my commitment to raising awareness and funds for pediatric cancer research and treatment," he continued. "We are working on a huge event for next year in support of our foundation, The Johnny Crisstopher Children’s Charitable Foundation, and will announce more details about it as things are confirmed. We want to thank you all for the outpouring of love, good thoughts and prayers for our amazing boy.
ET spoke with Angel in March at the renamed Criss Angel Theater at Planet Hollywood, where he talked about Johnny's health.
"Obviously, you know, I don't sleep very much but I'm so blessed," he told ET at the time. "I'm so thankful and I feel like all the success that I've been so blessed to have is really for a great cause -- and that is pediatric cancer. One child every two minutes is diagnosed with it. So, if you'd like to help out, you can go to crissangel.com, click the help button and donate and know that 100 percent of every cent you donate will go to research and treatment for these children suffering with this horrible disease."