"Right before I got here today, it came across the wire," Mandel shared, explaining that Macdonald's death was so surprising because, "Obviously, he wasn't [public] with his diagnosis."
"He gave me some of my favorite moments ever on SNL," Mandel shared. "He was so funny, so pure, so authentic, so real."
Mandel made a reference to the unfortunate news during Tuesday's show, after stand-up comedian Gina Brillon -- who is one of two comics to make it to the finals this year alongside Josh Blue -- delivered her comedy set to a roaring, laughing audience.
"I just want to say this because I need to, one of the greats of comedy passed today, Norm Macdonald passed today, and it broke my heart," Mandel shared while giving feedback after Brillon's performance. "Having you and seeing you and Josh on the show today brings us back and lets us know that laughter is still alive and laughter is the best medicine."
Mandel told ET after the show that having two talented comedians make it this far feels particularly special with the loss of Macdonald.
"I thought it was so fitting that on a day with so great a loss in the world of comedy that we here on AGT are celebrating comedy with two comedians in the final," he shared. "I thought, in honor of this great loss, maybe this could be a tribute to Norm Macdonald."
Lori Jo Hoekstra, Macdonald's longtime producing partner and friend, was with the comedian when he died, and told Deadline that, though Macdonald had been battling cancer for nearly a decade, he was determined to keep his health struggles private, and away from his family, friends and fans.
The Canadian-born Macdonald began his career as a writer on Roseanne, a job he held from 1992 to 1993. He went on to appear on Saturday Night Live from 1993 to 1998. He anchored the show's "Weekend Update" segment for three seasons. Following his SNL stint, Macdonald led his own sitcom, The Norm Show, for three years. Throughout his career, Macdonald appeared in films including Billy Madison, Funny People and Grown Ups, and TV series including Sunnyside, Girlboss and The Middle.
He is survived by his 28-year-old son, Dylan Macdonald.