"You know Zach, those are real out-of-date questions. You need to get out more," Clinton fired back.
Of course, the Hangover star didn't stop there. "What happens when you become pregnant? Are we gonna be stuck with (Democratic vice presidential nominee) Tim Kaine for nine months, how does this work?" he continued.
"I could send you some pamphlets that might help you understand," Clinton quipped.
Of course, some of their biggest digs came at the expense of Republican nominee Donald Trump. When Clinton says she thinks Trump will wear a "red power tie" to the upcoming debates, Galifianakis quipped, "Or maybe, like, a white power tie."
"That's even more appropriate," Clinton deadpanned.
But even the presidential hopeful couldn't come up with a response when Galifianakis joked, "When you see how well it works for Donald Trump, do you ever think to yourself, 'Oh, maybe I should be more racist?'"