Clooney was joined by Rande Gerber and Cindy Crawford, as well as Ryan Seacrest and Maria Menounos.
The actor stars as Neil Armstrong in the upcoming biopic about the first man to walk on the moon.
Clooney's A-list family and friends turned out to honor the Oscar winner as he received the AFI Life Achievement Award
ET caught up with the 57-year-old actor at AFI's 46th Life Achievement Award Gala Tribute in Los Angeles on Thursday, where he was being honored.
‘I couldn’t sleep when we were apart.’
ET spoke with George and Amal Clooney on Thursday in Los Angeles, where the actor was honored with the AFI Life Achievement Award. Tune in to the 'Tribute to George Clooney' on June 21 at 10 p.m. ET/PT on TNT.
ET caught up with the 57-year-old actor right before he was awarded the AFI Life Achievement Award at the American Film Institute's Gala in Hollywood on Thursday.
The actor and his wife, Amal, welcomed Ella and Alexander on June 6, 2017.
Little Ella and Alexander Clooney celebrated their first birthday on Wednesday.
The couple spent some time together ahead of their twins' first birthday.
"We had a little email exchange."
The actor will be honored on June 7 at the Dolby Theatre in Hollywood, CA.
The 'Roseanne' star got candid about working with George Clooney in the hit '90s.
The A-lister was the life of the party at Meghan Markle and Prince Harry's star-studded wedding reception at Frogmore House on Saturday.