But despite the loss (and missing out on little Alexis Olympia's first steps), she was graceful in defeat and positively winning in terms of her personal cheering section, husband Alexis Ohanian.
"Days after our baby girl was born, I kissed my wife goodbye before surgery and neither of us knew if she would be coming back. We just wanted her to survive -- 10 months later, she's in the #Wimbledon final," Ohanian wrote on Instagram on Sunday. "Congratulations, @angie.kerber. @serenawilliams will be holding a trophy again soon -- she's got the greatest one waiting at home for her. Our family knows she'll win many more trophies, too. She's just getting started. And I couldn't be more proud."
Still, Williams has already cemented her place in the annals of tennis history. Though she didn't win on Saturday, she remains tied for second all time with Steffi Graf with seven Wimbledon championships and is regarded as one of the greatest tennis players of all time.
For a look at Williams's longtime friendship with Meghan, watch the video below.