The new season of Scream Queens will pick up about two years after the events of season one, moving from the college campus to a hospital, where some of the most bizarre medical cases are under observation. Stamos will play Dr. Brock Holt, the hospital’s “brilliant, but secretive” head surgeon.
The 52-year-old actor will join returning cast members Jamie Lee Curtis, Emma Roberts, Lea Michele, Abigail Breslin, Keke Palmer, Billie Lourd, Glen Powell and Niecy Nash, who will all reprise their season one characters.
This marks a reunion of sorts for Stamos and Scream Queens creator Ryan Murphy, as he’s previously appeared in Glee and The New Normal. It also keeps Stamos in the Fox family after the network canceled his comedy, Grandfathered, in May after just one season.
In March, ET caught up with the cast and producers of Scream Queens at PaleyFest, where co-creator Brad Falchukteased the upcoming season.
"We can expect a lot of very strange patients," Falchuk told ET. "We can expect our characters interacting with them in different and odd ways. We can expect a lot of the same kind of humor, and a lot of the same kind of messaging."
Scream Queens will return Tuesday, Sept. 20 at 9 p.m. ET/PT on Fox.
To find out more about what fans can expect in season two, watch ET’s exclusive interviews below.